"Descubrir lo creado es crear la ciencia."


Académicos
DOCENTES/COMAS MAURICIO

Mauricio Comas García



Profesor Tiempo Completo Nivel VI
Perfil Prodep
Nivel SNI: I


Estudios

Licenciatura en Química
Facultad de Ciencias Químicas. Universidad Autónoma de San Luis Potosí
Periodo: 2002 – 2007, Graduado

Doctorado en Fisicoquímica
Departamento de Química y Bioquímica, Universidad de California, Los Ángeles
Periodo: Febrero 2007 – Agosto 2013. Graduado


Estancias Posdoctorales

Posdoctorado en Virología
Instituto Nacional de Cáncer de EE.UU
Periodo 2013 - 2018


Líneas de investigación

Empaquetamiento del genoma del virus de Chikungunya

Ensamblaje viral de la proteína de la cápside del virus de Chikungunya

Neurovirulencia del virus de Zika en células neurales troncales, neuronas, astrocitos y oligodendrocitos

Biología estructural por medio de microscopía electrónica de transmisión en secciones ultrafinas


Publicaciones recientes

    2022
  • Ulloa-Aguilar, J.M., Herrera Moro-Huitron, L., Cruz-Holguin, VJ., Lopez-Ortega, O., Helguera-Repetto A.C., Comas-Garcia, M, Miranda-Labra, R.U., León-Juarez, M. (2022). Immune response to Respiratory Syncytial Virus Infection: The Inclusion Bodies as evasion structures of the immune response. Submitted.
  • Ojeda-Galván, H.J., Hernández-Arteaga, A.C., Toro-Vázquez, J.F. Cruz-González, N., Ortiz-Chávez, S., Comas-Garcia, M., Rodriguez-Vázquez, A.G., Navarro-Contreras, H.R. (2022). Applicatio of Raman Spectroscopy of proten denaturaiton and aminoo acid decomposition temperatures. Submitted
    • 2021
  • García Silva, I.*, Colunga-Saucedo, M.*, Almendarez-Rodríguez, C., Miranda-López, C., Rosales-Mendoza, S., & Comas-Garcia, M. Chapter 10. VLP-based vaccines against SARS-CoV-2. Biomedical Innovations to Combat COVID-19 1st Ed. Elsevier. October 19th, 2021. ISBN 9780323902489
  • Comas-Garcia, M., Rubio-Hernández, E.I., Lara-Hernández, I., Colunga-Saucedo, M, Castillo, C.G., Comas-Garcia, A., Monsivais-Urenda, A., Zandi, R. (2021). Chapter 1. Basic virology aspects of SARS-CoV-2. Biomedical Innovations to Combat COVID-19 1st Ed. Elsevier. October 19th, 2021. ISBN 9780323902489
  • Lara-Hernández, I., Cornado-Ipiña, M.A., Rocha-Rosas, K., Comas-Garcia, M. Chapter 2. Fundamental aspects of the structural biology of Coronaviruses. Biomedical Innovations to Combat COVID-19 1st Ed. October 19th, 2021. ISBN 9780323902489
  • Farfán-Castro, S., García-Soto, M., Comas-Garcia, M., Arévalo-Villalobos, J., Palestino, G., González-Ortega, O., Rosales-Mendoza, S. (2021) Synthesis and immunogenicity assessment of a gold nanoparticle conjugate for the delivery of a peptide from SARS-CoV-2. Nanomedicine: Nanotechnology, Biology, and Medicine. 34, 102372.
    • 2020
  • Comas-Garcia, M., Colunga-Saucedo, M. & Rosales-Mendoza, S. (2020) The role of virus-like-particles in medical biotechnology. Molecular Pharmaceutics 17 (12), 4407-4420
  • Rosales-Mendoza, S. Comas-Garcia, M. & Korban, S.S. (2020) Challenges and Opportunities in Pursuing Science During the Coronavirus Pandemic. Trends in Biotechnology 38(8); 823
    • 2019
  • Comas-Garcia, M. (2019) Packaging of Genomic RNA in Positive-Sense Single-Stranded RNA viruses: A Complex Story. Viruses 11(3), 253 Selected as part of the special edition "Viruses 10-year anniversary".
    • 2018
  • Comas-Garcia, M., Kroupa, T., Datta, S.A.K., Harvin, D.P., Hu, W.S. & Rein, A. (2018) Efficient support of virus-like-particle assembly by the HIV-1 packaging signal. eLife 2018;7:e38438.
    • 2017
  • Comas-Garcia, M., Datta, S.A.K., Baker, L., Varma, R., Gudla, P.R. & Rein, A. (2017) Dissection of specific binding of HIV-1 Gag to the “packaging signal” in viral RNA. eLife 2017;6:e27055.
    • 2016
  • Comas-Garcia, M., Davis, S.R. Rein, A. (2016) On the selective packaging of genomic RNA of HIV-1. Viruses 8(9) 246.
  • Torres-Salgado, J.F., Comas-Garcia, M., Villagrana-Escareno, M.V., Duran-Meza, A., Ruiz-Garcia, J. & Cadena-Nava, R.D. (2016) Physicochemical study of viral nanoparticles at the Air/Water interface. The Journal of Physical Chemistry B 120(26):5864-5873.
  • Bruinsma, R.F., Comas-Garcia, M., Garmann, R.F. & Grosberg, A.Y. (2016) Quasi-equilibrium self-assembly of small RNA viruses. Physical Review E 93(3):032405.
  • Garmann, F.R., Comas-Garcia, M., Gopal, A., Knobler, C.M. & Gelbart, W.M. (2016) Physical principles in the self-assembly of a simple spherical virus. Accounts of Chemical Research 49(1): 48-55.
    • 2014
  • Garmann, F.R., Comas-Garcia, M.,, Koay, M.S.T., Cornelissen, J.J.L.M., Knobler, C.M. & Gelbart, W.M. (2014) Role of Electrostatics in the Assembly Pathway of a single-stranded RNA virus. Journal of Virology 88(18):10472-10479.
  • Comas-Garcia, M., Garmann, F.R., Singaram, S.W., Ben-Shaul, A., Knobler, C.M. & Gelbart, W.M. (2014) Characterization of viral capsid protein self-assembly around short single-stranded RNA. The Journal of Physical Chemistry B 118(27): 7510-7519.
  • Garmann, F.R., Comas-Garcia, M., Gopal, A., Knobler, C.M. & Gelbart, W.M. (2014) The assembly pathway of an icosahedral single-stranded RNA virus depends on the strength of inter-subunit attractions. The Journal of Molecular Biology 462(5):1050-1060.
    • 2012
  • Comas-Garcia, M., Cadena-Nava, R.D., Rao, A.L.N., Knobler, C.M. & Gelbart, W.M. (2012) In vitro quantification of the relative packaging efficiency of a single-stranded RNA molecules by viral capsid protein. Journal of Virology Volume 86, Number 22, 12271-12282
  • Cadena-Nava, R.D., Comas-Garcia, M., Garmann, R.F., Rao, A.L.N., Knobler, C.M., & Gelbart, W.M. (2012) Self-assembly of viral capsid protein and RNA molecules of different sizes: requirement for a specific high protein/RNA mass ratio. Journal of Virology Volume 86, Number 6, 3318-3326

Contacto

Teléfono (Oficina Facultad de Ciencias): (444)- 826-2300 ext. 5690
Teléfono (Oficina CICSAB): (444)- 826-1450 ext. 8551
Correo electrónico: mauricio.comas@uaslp.mx
Sitio de Investigadores UASLP: Mauricio Comas
Sitio de Investigadores CICSAB: Mauricio Comas
Sitio Web Personal: Mauricio Comas